Molecular Parameters of Hyperthermia for Radiosensitization
نویسندگان
چکیده
منابع مشابه
Radiosensitization with Hyperthermia and Chemotherapeutic Agents: Effects on Linear-Quadratic Parameters of Radiation Cell Survival Curves
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Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization.
Hyperthermia is a potent sensitizer of cell killing by ionizing radiation (IR); however, hyperthermia also induces heat shock protein 70 (HSP70) synthesis and HSP70 expression is associated with radioresistance. Because HSP70 interacts with the telomerase complex and expression of the telomerase catalytic unit (hTERT) extends the life span of the human cells, we determined if heat shock influen...
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Malignant hyperthermia (MH) is triggered by all inhalative anesthetics as well as depolarizing muscle relaxants in genetically predisposed individuals. Presymptomatic testing is important in this potentially fatal pharmacogenetic disease. In vitro challenging of muscle samples with halothane and caffeine is the basis of contracture testing, which until recently was the only accepted diagnostic ...
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ژورنال
عنوان ژورنال: Critical Reviews™ in Eukaryotic Gene Expression
سال: 2009
ISSN: 1045-4403
DOI: 10.1615/critreveukargeneexpr.v19.i3.50